The overall objective of this project is to improve treatment decision making process for aCRC/mCRC patients, incorporating the challenges introduced from cost restrictions, toxicity and tumor's drug resistance.
Analytical models will be developed to address how existing clinical data can be used to answer the following questions:
- Which chemotherapy regimen should be administered given patient's demographics, disease characteristics, and current toxicity levels?
- At what time point each chemotherapy drug should be administered given the history of treatment?
- For how long each treatment should be given to a patient to avoid tumor resistance?
- What is the best treatment choice for each patient under a particular budget?